Cortical Excitability Using Transcranial Magnetic Stimulation and Neuronavigation Device

Study of Cortical Excitability in Healthy Subjects With Transcranial Magnetic Stimulation (TMS) and a Neuronavigation Device

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02596789

Acronym

RC-TMS

Enrollment

Registered

2015-11-04

Start date

2012-06-30

Completion date

2016-06-30

Last updated

2017-05-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy Volunteers

Brief summary

This study has two main goals : * to investigate the impact of aging on cortical excitability (CE) * to investigate the impact of state dependency on CE, using a cognitive task and an emotional one. A Neuronavigation system of transcranial magnetic stimulation is used, and electromyographic response are recorded.

Interventions

DEVICETMS Magpro®, Magventure Inc device

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* male or female * age 18-75 * signed informed consent * normal physical examination

Exclusion criteria

* less 18 or more 75 years of age * contra indication to TMS: epilepsia or seizures, metallic head devices, cardiac pacemaker, pregnancy, jet lag or severe insomnia the night before * severe physical disease * treatment with psychotropic drugs * overt psychiatric disease * alcohol consumption before the examination

Design outcomes

Primary

Measure	Time frame	Description
Amplitudes of Motor evoked Potentials (µV) for ICI and ICF.	Participants will be followed for an expected average of one month	Motor Evoked Potential (MEP) from the first dorsal interosseous are register during the stimulations. Intracortical Inhibition (ICI) and Facilitation (ICF) are a paired-pulse TMS measure of cortical excitability. A short Interval interstimuli (2ms) leads to a cortical inhibition, which reflects the GABAergic neurotransmission; whereas a longer interval interstimuli leads to a cortical facilitation, which reflects glutamatergic neurotransmission.
Durations of Cortical Silent Period (ms)	Participants will be followed for an expected average of one month	Cortical Silent Period (CSP) is a single-pulse TMS measure of cortical inhibition, stimulations are applied while subjects are exerting a muscular contraction of the thum-index pinch and lead to a muscular cancellation. Duration of this silence is measured.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026