Surgery in Early Childhood
Conditions
Brief summary
The central hypothesis is that surgery and anesthesia exposure in children with immature structural and functional brain development has long-term adverse effects on child development at school-entry compared with children not exposed to anesthesia. The secondary hypothesis is that frequency of surgery and anesthesia exposure in children with immature structural and functional brain development has a dose-dependent association with worsened child development outcomes at school-entry. The overall objective is to investigate the association between surgery/anesthesia exposure(s) in children in Ontario and major child development outcomes (physical health and well being, social competence, emotional maturity, and language and cognitive development) at school entry as measured by the Early Development Instrument.
Interventions
OTHERSurgery in early childhood
Surgical interventions in early childhood (prior to completion of Early Development Instrument)
Sponsors
McMaster University
Institute for Clinical Evaluative Sciences
The Hospital for Sick Children
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 6 Years
Healthy volunteers
No
Inclusion criteria
* Completion of the Early Development Instrument in Ontario
Exclusion criteria
* Children with physical or developmental disabilities identified in the Early Development Instrument * Not born in Canada * Having undergone fetal interventions, radiation or brachytherapy, local pharmacotherapy, systemic cancer chemotherapeutic procedures, therapeutic interventions of the cardiovascular system * Patients of a cardiology or cardiovascular service
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Early developmental vulnerability | Assessed between five and six years of age | Any major domain of the Early Development Instrument in the lowest 10th percentile |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Performance in specific Early Development Instrument domains | Assessed between five and six years of age | Vulnerability (percentage in lowest 10th centile); mean score |
| Multiple challenge index | Assessed between five and six years of age | Vulnerability (percentage in lowest 10th centile) in ≥9 sub-domains of the Early Development Instrument |
Countries
Canada
Outcome results
None listed