Acute Kidney Injury
Conditions
Keywords
AKI, Extracorporeal Carbon Dioxide Removal, Renal Replacement Therapy, Mechanical Ventilation
Brief summary
This study aims to assess whether in patients with acute kidney injury (AKI) requiring mechanical ventilation, a strategy that combines renal replacement therapy (RRT) and extracorporeal carbon dioxide removal (ECCO2R) allows reduction of tidal volume and plateau pressure. Systemic Inflammatory Response and Safety Variables will also be analysed.
Interventions
DEVICERRT plus ECCO2R
Patients with acute kidney injury will be treated with Renal replacement therapy associated to extracorporeal carbon dioxide removal in a single treatment
Sponsors
University of Turin, Italy
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients with acute kidney injury (AKI) requiring renal-replacement therapy and mechanical ventilation of duration ≥ 48 hours
Exclusion criteria
* little chance of survival at 24 h (according to clinical judgment), pregnancy, mechanical ventilation with expected duration lower than 48h, age under 18 and over 90
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Achievement of tidal volume reduction to 4 mL/kg while maintaining pH and PaCO2 to ± 20% of baseline values | 72 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of inflammatory mediators release in plasma samples of patients | 72 hours | Plasma Concentrations of interleukin 6, interleukin 8, interleukin 1 beta, tumor necrosis factor alpha |
| Assessment of the changes in pH | 72 hours | — |
| Assessment of the changes in PaCO2 | 72 hours | — |
| Assessment of the changes in PaO2 | 72 hours | — |
Countries
Italy
Outcome results
None listed