Influence of Depth of Anesthesia on Pupillary Reactivity to a Standardized Stimulus

The Influence of Depth of Anesthesia on Pupillary Reactivity to a Standardized Stimulus Under Steady-state Remifentanil Analgesia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02595476

Enrollment

Registered

2015-11-03

Start date

2015-01-31

Completion date

2016-03-31

Last updated

2017-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Keywords

analgesia, pupillometry, general anesthesia

Brief summary

A standardized tetanic stimulation is applied to patients under propofol-remifentanil TCI, in a cross-over fashion, at two different levels of anesthesia monitored by the BIS: BIS 25 and BIS 55. Remifentanil target remains constant during the whole study period (1 ng/ml). Pupillary reflex dilation is recorded after each stimulation.

Interventions

DRUGRemifentanil

DRUGpropofol

DEVICETCI

PROCEDURETetanic stimulation

DEVICEAlgiscan

Pupillometry

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

10 Years to 20 Years

Healthy volunteers

Inclusion criteria

* ASA 1-2 * scheduled for an idiopathic scoliosis surgical correction

Exclusion criteria

* Ophtalmologic pathology * Neurologic or muscular pathology * Metabolic pathology * Chronic pain

Design outcomes

Primary

Measure	Time frame	Description
Post-stimulation Pupillary reflex dilation	30 seconds	percentage of dilation compared to pre-stimulation pupillary diameter

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026