Atopic Dermatitis
Conditions
Keywords
atopic dermatitis
Brief summary
The goal is this study is to investigate the effects of dilute bleach on the skin of subjects with atopic dermatitis and those with healthy skin. The second goal is to evaluate the effects of different moisturizers on the skin barrier of subjects with and without atopic dermatitis. The investigators hypothesize that the bleach bath will increase the skin pH, decrease the skin hydration, and increase skin water loss in all study subjects. Secondly, the investigators hypothesize that moisturizers with the lowest pH and the highest water to oil ratio will result in improved skin barrier function. Furthermore, the investigators believe there will be a greater improvement in patients with atopic dermatitis.
Detailed description
The study has two main parts. Subjects in both groups will have one forearm in a dilute bleach bath and the other arm in a water bath for 10 minutes. The change in skin will be measured using different painless devices. The second part of the study involves application of 4 various moisturizers. The change in skin will be measured over a period of time using the non-invasive devices.
Interventions
OTHERBleach Bath and Moisturizers
All subjects will have one forearm in a bleach bath and the other forearm in a water bath for 10 minutes. Following the bath, skin barrier function will be evaluated. Secondly, moisturizers will be applied to the arms and the skin barrier will be evaluated overtime.
Sponsors
University of California, Davis
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
8 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 8 years to 65 years * Has been diagnosed with atopic dermatitis by a board-certified dermatologist at UC Davis * Subject/parents/legal guardians able to read and comprehend the study procedure and consent forms.
Exclusion criteria
* Those who are pregnant, prisoners, or cognitively impaired * Those who do not fit the inclusion criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in transepidermal water loss post-bath immersion | 10 minutes post-bath immersion | Subjects will immerse one randomized arm in a bleach bath and the other arm in a water bath for 10 minutes. The skin barrier function will be evaluated for change in transepidermal water loss after 10 minutes of bath immersion. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in transepidermal water loss after moisturizer application | up to 60 minutes post-moisturizer application | Each subject will have 4 various moisturizers placed on each arm. The skin barrier function will be measured for change in transepidermal water loss to 60 minutes post-application.. |
| Change in skin hydration after moisturizer application | up to 60 minutes post-moisturizer application | Each subject will have 4 various moisturizers placed on each arm. The skin barrier function will be measured for change in skin hydration up to 60 minutes post-application.. |
| Change in skin pH after moisturizer application | up to 60 minutes post-moisturizer application | Each subject will have 4 various moisturizers placed on each arm. The skin barrier function will be measured for change in skin pH up to 60 minutes post-application.. |
| Change in skin hydration post-bath immersion | 10 minutes post-bath immersion | Subjects will immerse one randomized arm in a bleach bath and the other arm in a water bath for 10 minutes. The skin barrier function will be evaluated for change in skin hydration after 10 minutes of bath immersion. |
| Change in skin pH post-bath immersion | 10 minutes post-bath immersion | Subjects will immerse one randomized arm in a bleach bath and the other arm in a water bath for 10 minutes. The skin barrier function will be evaluated for change in skin pH after 10 minutes of bath immersion. |
Countries
United States
Outcome results
None listed