Healthy, Imbalance of Constituents of Food Intake
Conditions
Brief summary
The aim of the trial is to investigate the effect of ingestion of 75g of glucose (with or without phosphorus) on diet induced thermogenesis (using indirect calorimetry) and appetite (using visual analogue scales) in lean and obese healthy subjects
Interventions
Sponsors
Study design
Eligibility
Inclusion criteria
* Healthy * Sedentary lifestyle * Stable weight for the past 3 months * On a balanced diet
Exclusion criteria
* Underweight (BMI\<18.5) or overweight/obese (BMI≥25) * age \<18 or \> 30 years * Inability to give valid consent * Presence of a chronic or acute illness. * Elevated physical activity level (assesses by the physical activity questionnaire) * Heavy smokers (≥1 pack per day). * Weight gain or loss of \> 3% in the past 3 months * History of kidney stones
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diet Induced Thermogenesis | 180 minutes (measured every 30 min) | Diet Induced Thermogenesis will be measured using indirect calorimetry (VO2 consumption) |