Skip to content

Pedal Rate Influence on Oxygen Consumption in Eccentric

Pedal Rate Influence on Oxygen Consumption in Eccentric

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT02594657
Acronym
PRIOx
Enrollment
15
Registered
2015-11-03
Start date
2015-08-31
Completion date
2016-10-31
Last updated
2016-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Eccentric, Ergometer, Pedal rate, Oxygen consumption, Only health volunteers

Brief summary

Nowadays, ECC exercise can be realized using various modalities that target small or large muscle masses in a segmentary or dynamic way. The training program proposed in this study is realised on an handmade ergocycle which allows eccentric contractions. With this type of ergometer, O2 consumption (VO2) is three to five fold lower than during an exercise realised at the same power output with a concentric ergocycle. Due to this later propertie, which origins are not yet fully identified, there is an increasing interest to embed ECC in rehabilitation programs. The investigators hypothesis that a higher pedal rate will induce a lower oxygen consumption, with the same benefits. This study aims to compare oxygen consumption at two pedal rates : 50 and 80 rotation per minute (rpm). The ultimate goal is to assess efficacy and tolerance of eccentric training on ergocycle and to enhance comprehension of the physiological mecanisms involved in the lower O2 consumption observed.

Detailed description

The training program proposed in this study is realised on an handmade ergocycle which allows almost pur eccentric contractions. Fifteen healthy volunteers realize a incremental test until exertion on a concentric ergometer. If the minimal power output of 200W is reached, the volunteers are familiarized with eccentric exercise during several bouts of exercise. This habituation session allows avoiding the secondary muscular effects of high intensity eccentric exercise. Then, volunteers could take part in a two-stepped eccentric protocol: 1) an incremental test consisting in 3 stages. Each stage lasts 4 minutes. 2\) A constant-load test realized at 320W during 6 minutes. Each test is realized twice: at 50 and 80 rpm and sequence is randomly assigned. \[One step (incremental or constant load) = two tests (50 and 80 rpm)\] During each step, oxygen consumption is continuously measured, as well as cardiac output and muscular activity and intramuscular oxygen kinetic.

Interventions

PROCEDUREpedal rate on 50 RPM

All measurements are performed in two pedalling situations. The two frequencies used will be 50 and 80 RPM. For each subject the running order (50 and 80, 80 and 50) is randomly determined

PROCEDUREpedal rate on 80 RPM

All measurements are performed in two pedalling situations. The two frequencies used will be 50 and 80 RPM. For each subject the running order (50 and 80, 80 and 50) is randomly determined

Sponsors

University Hospital, Clermont-Ferrand
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
NONE

Eligibility

Sex/Gender
MALE
Age
18 Years to 55 Years
Healthy volunteers
Yes

Inclusion criteria

* \- Males * IMC \<30 * physically active * Pmax concentric \> 200W * Pmax \> Pmax théo sédentaire

Exclusion criteria

* cardio pulmonary, osteo articulary or muscular diseases * Eccentric based physical activities or sports (weight liftering, alpine skiing)

Design outcomes

Primary

MeasureTime frameDescription
Oxygen consumption (VO2 ml/min)at day 1Oxygen consumption (VO2) is continuously assesse during exercises at 50 and 80 rpm.

Secondary

MeasureTime frameDescription
Cardiac output( l/min)at day 1
muscular oxygen kinetic (arbitrary unit and %)at day 1
Muscular activity (mV)at day 1 during one and half minute (1min30s)Muscular activity is measured during one and half minute, at the end of each stage
VO2 (ml/min)at day 1VO2 is continously assessed during the constant-load exercise

Countries

France

Contacts

Primary ContactPatrick LACARIN
placarin@chu-clermontferrand.fr04 73 75 11 95

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026