Chronic Periodontitis
Conditions
Brief summary
Platelet rich fibrin is a second generation platelet concentration which contains various growth factors. The aim of this study is to evaluate the clinical and biochemical efficacy of PRF in subjects of chronic periodontitis in the operation of conventional periodontal flap.
Detailed description
PRF was developed in 2001 by Choukroun in France, it was the second generation fibrin adhesive, and was used to accelerate the soft and hard tissue healing. Many studies have shown beneficial effects of PRF on osteoconductive filler material in sinus lift operations, treatment of periodontal sulcus defect and treatment of furcation defects. Also PRF contains many growth factors. PRF accelerates periodontal regeneration through the gradually excreted growth factors and contributes to the bone regeneration. In this study, the investigators evaluated the effect of PRF on growth factors and its contribution to periodontal regeneration in subjects with chronic periodontitis.
Interventions
DEVICEPlatelet Rich Fibrin
Platelet rich fibrin increases the growth factors. So it was applied for treatment of periodontal bone loss.
Only Conventional Flap Surgery treatment the bone loss limitedly.
Sponsors
Ataturk University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients with CP who had pocket depth ≤ 5 mm and at least two area (grouped as Control and PRF) with horizontal bone loss after Phase I therapy
Exclusion criteria
* The subjects excluded in the study had history of systemic disease, were smokers, had allergy to any drug, had need for prophylaxis of antibiotic and had taken antibiotics at least 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Levels of IGF-1, VEGF, BMP-2, FGF-2 on Weekly | 4 weeks | Change from baseline IGF-1, VEGF, BMP-2, FGF-2 levels of GCF at 1 month were measured by periopaper. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Alteration of Clinical Attachment Level | 6 month | Change from baseline Clinical Attachment Levels at 6 months were measured with periodontal probe. |
| Alteration of Periodontal Pocket Depth | 6 month | Change from baseline Pocket Depth at 6 months were measured with periodontal probe. |
Countries
Turkey (Türkiye)
Outcome results
None listed