Hypertension
Conditions
Brief summary
To evaluate the efficacy of renal artery stent combined with standardized medical therapy as treatment for renal artery stenosis.
Interventions
DEVICEstent
patients receiving renal artery stenting for renal artery atherosclerosis
DRUGAspirine
100mg Qd
DRUGClopidogrel
75mg Qd
DRUGLercanidipine
10-20mg Qd
Sponsors
Lee's Pharmaceutical Limited
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Age between 40 - 75 * Diameter of stenosis of renal artery or main branch of renal artery ≥60％. If diameter of stenosis is 60% - 75%, pressure difference between proximal and distal end ≥20 mm Hg (1mmHg=0.133kPa) or Captopril renography positive; * Systolic blood pressure before taking antihypertensive ≥180mmHg and/or diastolic blood pressure ≥110 mmHg; taking three antihypertensive including one diuretics with systolic blood pressure ≥140mmHg and/or ≥90 mmHg; * length of ipsilateral kidney is greater than 7.0cm.
Exclusion criteria
* Estimated glomerular filtration rate (eGFR) \<30 ml/ (min﹒1.73 m 2) \[eGFR (mL/min/1.73 m2) = 186.3 \* serum creatinine (mg/dl) -1.154 \* Age-0.203 \* 0.742 (female)\[11\]; * unstable condition and unable to tolerate interventional therapy; * anatomy of renal artery pathology not suitable for interventional therapy; * allergic to dihydropyridines; * III degree atrioventricular block * contrast allergy ; * any known malignant tumor; * non-compliant, history of alcoholism or drug abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glomerular filtration rate | 12 months |
| Blood pressure | 12 months |
Countries
China
Outcome results
None listed