Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation

In Vitro Study of the Effect of Exosomes Derived From Red Blood Cell Units on Platelet Function and Blood Coagulation in Healthy Volunteers' Blood

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02594345

Enrollment

Registered

2015-11-03

Start date

2015-10-31

Completion date

2015-12-31

Last updated

2016-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood Coagulation, Platelet Function

Brief summary

This study is designed to analyze the effect exosomes derived from red blood cell units have on blood coagulation and platelet function. It is an in vitro study using healthy volunteers' blood.

Detailed description

The blood of 25 healthy volunteers will be exposed to exosomes derived from red blood cell units. The effects on coagulation and platelet function will be measured using thromboelastometry (ROTEM®) and FACS analysis.

Interventions

OTHERin vitro study

Exosomes will be mixed with healthy volunteers' blood in vitro

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy volunteers

Exclusion criteria

* pregnancy * drug use

Design outcomes

Primary

Measure	Time frame	Description
clotting time	2 months	measured by thromboelastometry (ROTEM® Analysis)

Secondary

Measure	Time frame	Description
clot formation	1h after exposure	measured by thromboelastometry (ROTEM® Analysis)
clot stability	1h after exposure	measured by thromboelastometry (ROTEM® Analysis)
clot lysis	1h after exposure	measured by thromboelastometry (ROTEM® Analysis)
CD62P	3h after exposure	FACS analysis

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026