Supratentorial Neoplasms
Conditions
Brief summary
Total intravenous anaesthesia using propofol and remifentanil are routinely used drugs for this purpose. The hemodynamic stability and at the same time early emergency are the main goals following neurosurgery. However there is no standard for discontinuation time for manually controlled systems today. The investigators aimed to study the effect of remifentanil infusion alone for early emergence and hemodynamic stability during the closure period in patients undergoing supratentorial craniotomy.
Detailed description
Adult, American society of Anaesthesiologist score I-II, 80 patients who underwent elective supratentorial craniotomy for tumour resection were randomly assigned to group I or II. In group I; propofol was discontinued during the dural closure. After the propofol was discontinued, remifentanil dose was increased with the guidance of bispectral index spectrum and hemodynamic parameters. In group II; propofol discontinued before the end of the surgery. Time to awakening and extubation time, adverse events, total remifentanil and propofol consumptions and side effects were recorded. Heart rate and blood pressure were recorded during this period.
Interventions
DRUGRemifentanil
0.1-0.5 mcg/kg/min infusion
DRUGPropofol
75-200 mcg/kg/min infusion
Sponsors
Yeditepe University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* American Society of Anaesthesiologist physical status I-II * Glasgow Coma Scale score of 15 points * Elective supratentorial craniotomy for tumor resection * Supine position
Exclusion criteria
* Obese patient * Brain tumor greater than 30 mm in diameter * Postoperative cranial drainage * Hypertension * Diabetes mellitus * Reoperation * Pregnant * Breast feeding * Allergy to the study medications * History of cranial radiotherapy * Frontal bone flap * Intraoperative neuromonitoring
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time of extubation | 3 hours | After the surgery, starting from three-pin head holder removal, an investigator asked each patient to open his or her eyes, squeeze the investigator's hand. When the patient opened his or her eyes, obeyed commands, resumed adequate respiration, hemodynamically stable and bispectral index spectrum \> 70-80 was extubated, and the time will be recorded. The patients will be followed for an expected average of 3 hours. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart Rate | 6 hours | Heart rate per minute was recorded |
| Mean arterial pressure were recorded | 6 hours | Mean arterial pressure (mmHg) was recorded |
| Post-anesthesia awaking time | 3 hours | Post-anesthesia awaking time assessed as the interval (min:sec)required to |
Countries
Turkey (Türkiye)
Outcome results
None listed