Esophageal and Gastric Varices, Liver Cirrhosis
Conditions
Keywords
Liver cirrhosis, Esophageal and Gastric Varices, Endoscopy
Brief summary
Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding.
Detailed description
Esophageal variceal bleeding is one of the most lethal complications of liver cirrhosis. In the early stage of liver cirrhosis, the prediction of esophageal varices is very important for guiding the clinical decision making of primary prophylaxis of variceal bleeding. The investigators' recent systematic review evaluated the diagnostic accuracy of APRI, AAR, FIB-4, FI, King, Lok, Forns, and FibroIndex scores in predicting the presence of esophageal varices in liver cirrhosis. However, their diagnostic accuracy was low to moderate. Further study is warranted to establish a reliable score to predict the presence of high-risk esophageal varice in liver cirrhosis.
Interventions
PROCEDUREEndoscopy
Upper gastrointestinal endoscopy to evaluate the presence of any grade varices and high-risk varices.
Sponsors
General Hospital of Shenyang Military Region
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. A diagnosis of liver cirrhosis. 2. Age and sex are not limited. 3. Etiology of liver cirrhosis is not limited. 4. Routine laboratory data. 5. Upper gastrointestinal endoscopy.
Exclusion criteria
1. Non-cirrhotic portal hypertension. 2. Malignancy. 3. Absent laboratory data. 4. A previous diagnosis of esophageal varices. 5. A previous history of variceal bleeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of biochemical data with esophageal varices in liver cirrhosis | 18 months | The investigators firstly calculated the significant factors associated with the presence of esophageal varices, and then developed a score to predict the presence of esophageal varices in liver cirrhosis. |
Countries
China
Outcome results
None listed