Endothelial Function
Conditions
Keywords
asthma, endothelial function
Brief summary
The aim of the study is to assess the peripheral endothelial function in adult asthmatic patients and the relationship between the peripheral endothelial function and the pulmonary function.
Detailed description
The primary criteria is the peripheral endothelial function that will be assessed by the measure of flow-mediated dilation (reactive hyperemia-peripheral artery tone index). The pulmonary function will be assessed by the measures of the FEV1, the forced vital capacity (FVC) and the expiratory flow between 25% and 75% (FEF25-75%). The relationship between these parameters of the pulmonary function and the peripheral endothelial function will be analyzed. In addition, a relationship between peripheral endothelial function and the level of asthma control (Asthma Control Test (ACT)), the cardiovascular risk factors (SCORE INdex) and the treatment for asthma (controllers) will be also assessed.
Interventions
DEVICEEndopat
measure of peripheral endothelial function by the reactive hyperemia-peripheral artery tone index with a specific device (Endopat)
Sponsors
Hopital Foch
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* All patients must have a clear-cut history of asthma at the time of enrolment into the trial (eventually confirmed in the past and documented by an increased hyperresponsiveness to methacholine; or a bronchodilator reversibility to a beta-2-adrenergic drug).
Exclusion criteria
* Patients with unstable asthma * Patients with a significant acute disease other than asthma. A significant disease is defined as a disease which, in the opinion of the investigator, may influence the results of the trial. * Pregnant or nursing women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| measure of reactive hyperemia-peripheral artery tone index | day 1 | measure of reactive hyperemia-peripheral artery tone index |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| measure of expiratory flow between 25% and 75% (FEF25-75%) | day 1 | measure of expiratory flow between 25% and 75% (FEF25-75%) |
| measure of the forced expiratory flow in one second (FEV1) | day 1 | measure of the forced expiratory flow in one second (FEV1) |
| measure of the forced vital capacity (FVC) | day 1 | measure of the forced vital capacity (FVC) |
Countries
France
Outcome results
None listed