Extra Oesophageal Reflux, Laryngeal Cyst, Recurrent Respiratory Papillomatosis
Conditions
Keywords
recurrent respiratory papillomatosis, extra oesophageal reflux, laryngeal cyst, phonosurgery, oesophageal impedance
Brief summary
The purpose of the study was to determine, whether patients with recurrent respiratory papillomatosis (RRP) suffer from extra oesophageal reflux more often than patients with laryngeal cyst (control group).
Detailed description
Recurrent respiratory papillomatosis (RRP) is a chronic viral disease, which affects children and adults as well. It is characterised by grow of squamous cell tumours on mucosa of aerodigestive tract, with predilection for the larynx. The disease is caused by the human papillomavirus (HPV). However, in contrast to the low incidence of RRP, HPV prevalence is common. It is indicated that other factors may contribute to the pathogenesis of RRP. One such factor might be extraesophageal reflux (EER). We investigated whether patients with RRP suffer more often from EER.
Interventions
PROCEDURESurgical collection of histology specimen
Collection of a histology specimen from the vocal cords and rear laryngeal commissure
PROCEDUREPerformance of immunohistochemical analysis
Immunohistochemical analysis - presence of pepsin, HPV 6 and 11, HSV 2 and chlamydia trachomasis
Sponsors
University Hospital Ostrava
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* age 1-75 years * cooperating patients with laryngeal papillomatosis * patients tolerating impedance probe * signed informed consent, consent with the examinations * control group of patients with a cyst or vocal cord polyp (reflux finding score 0-2) and/or patients indicated to augmentation, medialization or lateralization of the vocal cords
Exclusion criteria
* patients non-tolerating impedance catheter * patients who do not understand Czech language * patients who do not proclaim consent with enrolment into the study * patients who do not proclaim consent with the planned examinations * patients after surgical treatment of tumour of the swallowing or respiratory tract
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of EER (percentage) | 36 months | The occurrence of extra oesophageal reflux will be assessed in both study groups. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Presence of pepsin | 36 months | The presence of pepsin (yes-no) will be assessed in both study groups. |
Countries
Czechia
Outcome results
None listed