Diabetes Mellitus, Type 2
Conditions
Keywords
Exercise, Appetite, Energy intake
Brief summary
Four months of interval walking (IW) training results in substantial weight loss in opposition to energy-expenditure matched continuous walking (CW) training. The reason for this is unclear. This study will assess if IW leads to greater exercise-induced suppression of appetite and ad libitum food intake compared to CW and no exercise. Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions: 1. One hour of rest (CON) 2. One hour of interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW) 3. One hour of continuous walking (CW) matched to IW with regards to energy-expenditure. After the interventions subjects will undergo a liquid mixed meal tolerance test (450 kCal), with regular measurements of appetite-related hormones (insulin, ghrelin, Leptin, Cholecystokinin, PYY). Three hours into the mixed meal tolerance test, a standardised ad-libitum meal test will be served and intake will recorded. Free-living energy intake via food records will be assessed during the following 32 hours.
Interventions
Sponsors
Rigshospitalet, Denmark
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
30 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Type 2 Diabetes Mellitus * BMI \> 25
Exclusion criteria
* Pregnancy * Smoking * Contraindication to increased levels of physical activity * Eating disorder * Insulin dependence
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ad-libitum meal energy intake | Initiated 3 hours after the intervention | Subjects will receive a standardized ad-libitum meal and energy intake will be assessed |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Free-living energy intake | For 32 hours following the ad-libitum meal. | Subjects will complete diet records for 32 hours following the ad-libitum meal and energy intake will be assessed. |
| Appetite-related hormones | Regularly during the 3 hours following the intervention | Appetite-related hormones (insulin, ghrelin, leptin, cholecyctokinin, PYY) will be analysed in blood samples collected regularly during the liquid mixed-meal tolerance test following the intervention |
| Satiety | Regular assessments for 36 hours following the intervention | Satiety questionaires will be completed at regular intervals after the intervention |
Countries
Denmark
Outcome results
None listed