Hedonic Perception and Brain Activity Response to Meal

Hedonic Perception and Brain Activity Response to Meal in Health and Functional Dyspepsia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02592239

Enrollment

Registered

2015-10-30

Start date

2014-11-30

Completion date

2017-06-30

Last updated

2017-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dyspepsia

Keywords

Functional brain MRI, functional dyspepsia, hedonic response

Brief summary

The purpose of this study is to determine the relationship between brain activity and the perception of subjective hedonic sensations in response to a meal using functional MRI.

Detailed description

Functional MRI brain imaging will be performed in patients with functional dyspepsia and healthy controls in basal conditions and after a palatable test meal. During the study, the cognitive response and the hedonic dimension will be measured using 10 score scales.

Interventions

DEVICEFunctional brain MRI

Functional brain MRI before and after test meal ingestion

DIETARY_SUPPLEMENTA warm ham and cheese sandwich and a 200 ml fruit juice

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

1. Age between 18 and 80 yrs 2. Body mass index between 18-30 Kg/m2 3. Right-handed

Exclusion criteria

1. Subjects with clinical history of eating-disorders 2. Subjects with clinical history of significant head-trauma 3. Subjects with known serious illness: clinically significant cardiac, vascular, liver, pulmonary, or psychiatric disorders (as evaluated by the Investigator). 4. Subjects with a known history of alcohol or drug abuse in the previous 6 months. 5. Subjects using medications with SNS effects that cannot be discontinued, such as: antidepressants, pregabalin, gabapentin. 6. Women that are pregnant or that are breast-feeding. 7. Claustrophobia

Design outcomes

Primary

Measure	Time frame	Description
Change in activity in specific brain regions measured by functional MRI	3 hours	To determine the brain response to a meal in patients with functional dyspepsia and healthy subjects.
Cognitive and hedonic perception measured on 10 score scales (composite outcome)	3 hours	To determine the cognitive and hedonic response to a meal in patients with functional dyspepsia and healthy subjects.

Secondary

Measure	Time frame	Description
Metabolomic response measured in serum by NMR spectroscopy	3 hours	To identify the metabolomic substrate of the cognitive and brain responses to a meal.

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026