Mild Cognitive Impairment
Conditions
Keywords
Life-logging, Cognitive Training, Mild Cognitive Impairment, Memory, Information and communications technology (ICT) in healthcare, Portable camera
Brief summary
Background: Mild Cognitive Impairment (MCI) is a risk factor for dementia and represents a critical window of opportunity to intervene and alter the trajectory of both cognitive and functional decline. Emerging life-logging technologies has shown a tremendous potential to increase autobiographical memory. Objective: The main goal of the present study is to develop a Cognitive Training program (CT) for MCI based on life-logging captured by a Wearable Camera (WeC) recording specific autobiographical episodes for stimulating posteriorly episodic memory. The challenge is to create an application to manage this large collection of images, which can be easily retrieved as events by users in a therapeutic context as a multimodal cognitive stimulation. The investigators will conduct a quasi-experimental design with non-equivalent control group, evaluating the effectiveness of the life-logging re-experiencing program immediately and 3-month follow-up period. Methodology: The design is a pretest, posttest and follow-up design, where 30 adults with MCI were sequentially allocated to one of two conditions: intervention or control group. All subjects wore a lifelogging WeC during two weeks, and subsequently they were generated several videos with the most relevant information of each event. Subjects in the Intervention Group will attend 1-hour individual training sessions 2 times per week for 14 8 weeks. Main outcomes measures will be cognitive, functional, emotional and quality of life measures, as well as biochemical measures (BDNF). Expected results: The investigators expect the outcomes to provide preliminary evidence that autobiographical experimentation CT programs can positively impact cognitive functioning and may represent an effective strategy to improve memory and functionality in those who begun to experience cognitive decline.
Interventions
BEHAVIORALReMemory-MCI training
BEHAVIORALControl intervention
Sponsors
University of Barcelona
Associació Vallès Amics de la Neurologia
Fundació La Marató de TV3
Consorci Sanitari de Terrassa
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
65 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* 65-90 years of age * Meet definition criteria for MCI (Petersen, 2004) * Be receiving CT at least three month in Day Hospital during three months or more; c) having memory complaint, usually verified by an informant * Having memory complaint, usually verified by an informant * Memory performance below the mean score for the corresponding age and education group * Having normal general cognitive functioning as determined by a Mini-Mental State Examination (MMSE) score \> o = 24 * Having a reliable caregiver who can supervise the patient's daily activities * Having Global clinical dementia rating scale score of 0.5 * Granted written informed consent accepting to participate in the study
Exclusion criteria
* Neurological, psychiatric or unstable medical disorders * Intellectual deficiency (Premorbid Intellectual Quotient (IQ) -Vocabulary- less 85) * Relevant hearing, vision, motor or language deficits * Less than 4 years of education e) acquisition of Catalonian or Spanish languages after 15 years old
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in memory after receiving treatment | after 16 sessions treatment and 3 months | Memory was measured using the Logical Memory Test from the Wechsler Memory Scale, IV version (WMS-IV, Spanish version); the International Shopping List Task and the One Card Learning Task from the computerized neurocognitive battery Cogstate. |
| Change in attention after receiving treatment | after 16 sessions treatment and 3 months | Attention was measured using the Identification Task from the computerized neurocognitive battery Cogstate and the Forward Digit Span from the Wechsler Adult Intelligence Scale, fourth edition (WAIS-IV) |
| Change in working memory after receiving treatment | after 16 sessions treatment and 3 months | orking memory was measured using the One Back Task from the computerized neurocognitive battery Cogstate and the Backward Digit Span from the Wechsler Adult Intelligence Scale, fourth edition (WAIS-IV). |
| Change in executive function, set-shifting after receiving treatment | after 16 sessions treatment and 3 months | Set-shifting was measured using the Colors Trails Test |
| Change in executive function,verbal fluency | after 16 sessions treatment and 3 months | erbal Fluency was measured using the Controlled Oral Word Association Test, spanish adaptation, and semantic fluency test using the category Animals |
| Change in executive function, inhibition after receiving treatment | after 16 sessions treatment and 3 months | Inhibition was measured using the Five Digit Test |
| Change in processing speed after receiving treatment | after 16 sessions treatment and 3 months | Processing speed was measured using the Detection Task from the computerized neurocognitive battery Cogstate battery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in patient and caregiver's perception of social support | after 16 sessions treatment and 3 months | Perception of social support was measured using the Duke-UNC Functional Social Support Questionnaire |
| Change in subjective memory complaints after receiving treatment | after 16 sessions treatment and 3 months | subjective memory complaints was measured using Memory Faiures of EveryDay (MFE) Test |
| Change in neuroplasticiy | after 16 sessions treatment and 3 months | neuroplasticiy was measured using Brain-derived neutrophic factor (BDNF) serum levels |
| Change in functional capacity after receiving treatment | after 16 sessions treatment and 3 months | Functional capacity was measured using Functional Assessment Questionnaire (FAQ) and the UCSD Performance-Based Skills Assessment (UPSA). |
| Change in depression and anxiety after receiving treatment | after 16 sessions treatment and 3 months | depression and anxiety were measured using the Hospital Anxiety and Depression Scale (HADS) |
| Change in quality of life | after 16 sessions treatment and 3 months | Quality of life was measured using Quality of Life-Alzheimer Disease (QoL-AD) |
| Change in Neuropsychiatric symptoms | after 16 sessions treatment and 3 months | Neuropsychiatric symptoms was measured using Neuropsychiatric Inventory Questionnaire (NPI) |
| Change in Caregiver Burden | after 16 sessions treatment and 3 months | Caregiver Burden was measured using the Zarit Caregiver Burden Scale |
| Change in patient's self-esteem | after 16 sessions treatment and 3 months | Self-Esteem was measured using the Rosenberg Self-Esteem Scale |
Outcome results
None listed