Lung Disease,Obstructive
Conditions
Keywords
Mechanical ventilation, Chronic obstructive pulmonary disease, Airway resistance, Bronchial dilation test
Brief summary
In the patients with COPD mechanical ventilation, the bronchial dilatation is very common. However, the evaluation of the efficacy of the medical examination and other subjective indicators, such as doctors, depends on the doctor's experience; at present, there is no objective evaluation index. For patients with mechanical ventilation, the risk of cross infection can not only increase the risk of cross infection, but also increase the workload of clinical doctors and nurses. Therefore, this study proposes an objective evaluation method to evaluate the response of COPD patients to bronchial dilation. The hypothesis of this study can be used to guide the clinical medication through the test of the bronchus. If the patients with bronchial dilation test positive were used in the test, the patients were not used. In this evaluation method, the changes of airway resistance were measured by the accurate measurement of the patients with inhaled bronchial dilatation.
Interventions
DRUGSalbutamol Aerosol
DRUGNo drugs
Sponsors
Primary-investigator,Bing Sun
snow
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Acute exacerbation of chronic obstructive pulmonary disease * The mechanical ventilation time of the outdoor endotracheal intubation in the intensive care unit was less than 48 hours
Exclusion criteria
* asthma * has received tracheotomy * long term mechanical ventilation (which has been accepted for more than 21 days). * severe pneumonia * Patients who cannot use a patient with bronchial dilation * there's a taboo on the use of a sedative. * refusal to participate in the study * 48 hours to pull out the tube
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| airway resistance | 1 day | The first test of bronchial dilatation |
| Respiratory mechanics index:PEEPi | 1 day | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical ventilation time | 28 days |
| length of hospital stay | 30 days |
| Costs of hospitalization expenses | 30 days |
| Routine blood test:Eosinophilic cells | 7days |
Countries
China
Contacts
Primary ContactXue Wang, MB
Backup ContactSun Bing, MD
Outcome results
None listed