Breast Cancer, Cognition, Cognitive Impairment
Conditions
Keywords
nutrition, physical activity, breast cancer survivor, cognition
Brief summary
The purpose of this study is to examine the relationship between nutrition, physical activity and brain function in breast cancer survivors.
Detailed description
The current study will examine the potential relationships between physical activity, dietary intake, body composition and cognition in breast cancer cancer survivors and age-matched women without a previous cancer diagnosis. Additionally, we will measure blood inflammatory markers to explore the relationship between lifestyle factors and inflammation. The study involves two, 1hr appointments at Texas State University. The first visit will include cognitive testing and body composition assessment. Participants will be given an activity monitor to wear for one week and a packet of questionnaires to complete at home. At the second visit, a fasted blood sample will be collected, and participants will complete a food frequency questionnaire.
Interventions
OTHERno intervention
Sponsors
Texas State University, San Marcos
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Breast cancer survivors must have completed primary treatment (chemotherapy, radiation therapy or both) within past 60 months * age-matched controls must have no previous cancer diagnosis * Female * no history of stroke, heart attack or transient ischemic attack * not currently pregnant; can speak, read, and write English * can attend all testing sessions * not blind or legally blind; nonsmoker * no current use of computer-based brain training games (e.g. Lumosity ®, BrainHQ ®).
Exclusion criteria
* male * \< 30 or \> 70 years of age * breast cancer survivor \> 60 months from last treatment or currently undergoing primary treatment * breast cancer survivor never treated with chemotherapy and/or radiation * previous cancer diagnosis other than breast cancer
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognition | Baseline | A series of computer-based cognitive tasks will be administered via the NIH Toolbox Cognition Battery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diet Quality | Baseline | Diet will be assessed by completion of the online-administered 2005 Block Food Frequency Questionnaire |
| Body Composition (objectively measured) | Baseline | Body composition will be evaluated by BOD POD assessment |
| Physical Activity | Baseline | Physical activity will be measured by a waist-worn accelerometer |
| Inflammatory Markers | Baseline | A fasted blood sample will be collected for measurement of inflammatory markers |
Other
| Measure | Time frame | Description |
|---|---|---|
| Medical History | Baseline | Self-reported medical history |
| Quality of Life | Baseline | Series of questionnaires assessing various aspects of quality of life including physical and mental health |
Countries
United States
Outcome results
None listed