Malabsorption
Conditions
Brief summary
The purpose of this study is to evaluate amino acid absorption with two different type of proteins.
Interventions
DIETARY_SUPPLEMENTEnteral nutrition
Sponsors
Société des Produits Nestlé (SPN)
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with gastrointestinal disorder : citrulline plasma concentration \< 20 µmol/L and/or xylose plasma concentration \< 1,7 mmol/L * Patient under enteral nutrition at home * Patient already receiving 1 L by day
Exclusion criteria
* Obese patient BMI \> 30 * Diabetes * Renal or liver failure * Glucocorticoids treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Amino acid absorption profile | 48 hours | Area under the curve of amino acid plasma concentration |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tolerance | 48 hours | Description and occurence of adverse events |
| Nutritional status | 48 hours | Retinol Binding Protein and Transthyretin dosage |
| Essentials amino acid absorption | 48 hours | Area under the curve of plasma concentration |
| Insulinemia evolution | 48 hours | Insulinemia dosage |
| Link between amino acid and insuline | 48 hours | Correlation coefficient |
Countries
France
Outcome results
None listed