Exploratory Behavior
Conditions
Brief summary
The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.
Interventions
DIETARY_SUPPLEMENTtap water
300ml tap water via nasogastric tube
DIETARY_SUPPLEMENTGlucose
300ml tap water with 75g Glucose via nasogastric tube
DIETARY_SUPPLEMENTFructose
300ml tap water with 25g Fructose via nasogastric tube
Sponsors
University Hospital, Basel, Switzerland
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* right-handed healthy males, no drugs, non-smoking
Exclusion criteria
* drug abuse, smoker, left-handed, claustrophobia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow | changes from baseline to one hour after treatment |
Secondary
| Measure | Time frame |
|---|---|
| Changes in plasma insulin | changes from baseline to one hour after treatment |
| Changes in plasma glucose | changes from baseline to one hour after treatment |
| Changes in plasma GLP-1 | changes from baseline to one hour after treatment |
Outcome results
None listed