Obesity
Conditions
Brief summary
Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.
Detailed description
Excessive cardiac fat accumulation have been recognized to be associate to increased cardiac and metabolic risk. More effective treatments are needed to induce changes in cardiac fat content, body composition, and cardiac fat metabolic activity that result in a reduction in cardiovascular risk in overweight and obese population. Despite this need, little is known about which mode, frequency, and duration of exercise will allow for greater reductions in cardiac fat, improvements in body composition, restoration of a healthy cardiac fat metabolic activity, and improvement on cardiovascular risk markers. The aim of this study the effects of exercise in cardiac fat content, cardiac function, physical fitness, and metabolic activity in obesity.
Interventions
OTHERExercise Intervention
The intervention will consist of 3 weeks of whole body circuit training (resistance training) where participants in the intervention group will perform 7 different exercises. The circuit will consist of 10 repetitions per exercise of 7 exercises: leg press, bent-over row, bench press, squats, dumbbell jump squats with raises, dead-lifts and weighted abdominal crunches, with approximately 30 sec of rest in between each exercise (based on the estimated time needed to move from one position to the next). Each participant will move through the circuit 3 times, with 2 to 3 minutes of rest between each round. Intensity will be 6-7 of RPE at the first set, and 9-10 at the third set.
Sponsors
Texas Tech University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 30-39.99 * White/Caucasian
Exclusion criteria
* Known health problems such as cardiovascular, pulmonary or metabolic disease will be excluded. * Pregnant females. * Any adults found taking medications that affect endocrine or cardiovascular function will also be excluded from the study. * Participants that exercise more than three times per week or strength train more than twice per week. * Individuals that have poor venous access or have expressed a fear of needles or having blood taken will also be excluded. * Cigarette smoking (current or those who quit within the previous 6 months * Hypertension * Diabetics * MRI
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Cardiac fat volumes | 2 assessment points: at baseline and week 4 | Cardiac fat volumes will be assessed by means of Magnetic Resonance Imaging |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Vascular function | 2 assessment points: at baseline and week 4 | Vascular function will be assessed by means of Arterial Tonometry |
| Changes in Cardiorespiratory Function | 2 assessment points: at baseline and week 4 | Cardiorespiratory Function will be assessed on a treadmill test with a 12-lead EKG. Protocol: Modified Bruce (A baseline stage will be added) |
| Changes in Muscular Strength | 2 assessment points: at baseline and week 4 | Muscular Strength in upper and lower extremities will be assessed by 1 repetition maximum (1RM) test on Bench Press and Leg Press |
| Changes in Body Composition | 2 assessment points: at baseline and week 4 | Body Composition will be assessed using Dual-energy x-ray absorptiometry |
| Changes in Diet | 5 assessment points: baseline, week 1, 2, 3, and 4 | Diet will be assessed using the ASA24h recall (http://epi.grants.cancer.gov/asa24/) |
| Changes in Spontaneous Physical Activity | Baseline and week 4 | Spontaneous Physical Activity will be assessed using accelerometers Actical. |
| Changes in Oxidative stress markers | 5 assessment points: pre-post during session 1, pre-post during session 9, and pre week 4. | Blood will be collected and processed in order to assess oxidative stress markers |
Countries
United States
Outcome results
None listed