Diabetes Complications
Conditions
Brief summary
This case-control study investigated B-vitamin and homocysteine in relation to the presence or the absence of type 2 diabetes and clinical signs of polyneuropathy.
Detailed description
Blood samples were collected and clinical investigations were performed at the same time.
Interventions
DEVICEBlood collection and electrophysiological tests
Blood collected using a conventional method. Electrophysiology was tested after nerve Stimulation. Medical history and symptoms were collected after a standardized interview.
Sponsors
Universität des Saarlandes
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Male and female subjects with or without diabetes.
Exclusion criteria
* Usage of supplements containing B-vitamins, methotrexate treatment, cerebral or cardiac events in the last three months * Liver or renal dysfunction.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Red blood cell cobalamin levels | Baseline | — |
| Polyneuropathy grade estimated using a score including a combination of data from questionnaire and electrophysiology investigations | Baseline | Polyneuropathy grade was accessed using a questionnaire and a clinical examination (electrophysiology) after nerve stimulation. A score includes the combination of questionnaire data and electrophysiology data. |
Secondary
| Measure | Time frame |
|---|---|
| Plasma methylmalonic acid levels | Baseline |
| Plasma choline levels | Baseline |
| Plasma cobalamin levels | Baseline |
Countries
Germany
Outcome results
None listed