Hepatectomy, Surgical Blood Loss, Terlipressin
Conditions
Keywords
Hepatectomy, Surgical Blood Loss, terlipressin
Brief summary
To evaluate the effects of Terlipressin infusion on blood loss & transfusion requirements in cirrhotic patients undergoing major liver resections.
Interventions
DRUGTerlipressin
Terlipressin will be given as an intravenous injection of 2μg/kg/h to be continued throughout the surgery and weaned off over four hours postoperatively.
DRUGnormal saline
Same volumes of normal saline infusion, throughout the operation then gradually withdrawn over 4 hours.
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All patients older than 18 years of age, American Society of Anesthesiology (ASA) classification class I and II and assigned for elective resection of 2 or more liver segments portal hypertension
Exclusion criteria
* Patients with Child-Turcotte-Pugh grade B or C, clinically significant portal hypertension (splenomegaly, thrombocytopenia with platelets \< 1011/L, esophageal varices grade 2 or more), Preoperative renal failure (GFR \< 50ml/min), heart failure, Bradyarrhythmia (heart rate \< 60/min), history of hemorrhagic stroke, Uncontrolled arterial hypertension (Blood pressure \>160/100mmHg), and Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| blood loss | intraoperative period | blood loss in ml |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood units transfused | intraoperative period | number of packed RBCs units transfused |
| lactate level | at start and end of resection | lactate level in blood gas sample in mmol/L |
Countries
Egypt
Outcome results
None listed