Comparison Between High-density Electroencephalography and Conventional Electroencephalography for Comatose Patients

Comparison Between High-density Electroencephalography and Conventional Electroencephalography to Diagnose the Presence of Consciousness in Post-anoxic Comatose Patients

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02588482

Acronym

COMETIQUE

Enrollment

Registered

2015-10-27

Start date

2013-06-17

Completion date

2020-07-08

Last updated

2022-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Anoxic Coma

Keywords

electroencephalography (EEG), mismatch negativity (MMN)

Brief summary

The purpose of this study is to measure whether high-density electroencephalography can improve the detection of electrophysiological signs of awareness compared to conventional electroencephalography in post-anoxic comatose patients

Interventions

DEVICEhigh-density electroencephalography

Auditory stimulations during electroencephalography recording

DEVICEConventional electroencephalography

Auditory stimulations during electroencephalography recording

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* post anoxic coma * over 18 years old * agreement from families * alive 4 days after the beginning of coma

Exclusion criteria

* traumatic coma * non-traumatic but not anoxic coma * patients with severe comorbidity previous to coma * refusal of families to participate to the study * contraindication to a high-density electroencephalography exam

Design outcomes

Primary

Measure	Time frame	Description
Number of patients who recovered and who presented a mismatch negativity in high-density but not conventional electroencephalography	4 days after the beginning of coma	mismatch negativity is an electrophysiological response recorded after the presentation of deviant auditory stimulations Recovery is assessed 1 month after the beginning of coma

Secondary

Measure	Time frame
Number of patients who recovered and who presented a mismatch negativity in high-density but not conventional electroencephalography	7 days after the beginning of coma

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026