Effects of; Anesthesia, in Labor and Delivery
Conditions
Brief summary
To evaluate the effectiveness of adding dexamethasone to intrathecal levobupivacaine in combined spinal epidural (CSE) analgesia during vaginal delivery.
Detailed description
This prospective double-blind trial included 80 primigravidas during vaginal delivery with a cervical dilatation ≥ 4 cm and 50% effacement randomly assigned to one of two equal groups; Group L received intrathecal levobupivacaine 0.25% in 2 mL and Group LD received intrathecal levobupivacaine 0.25% combined with dexamethasone 4 mg in 2 mL. At first request of analgesia, a combination of 0.25% levobupivacaine with 100 μg fentanyl in 10 ml via the epidural catheter. Further analgesia was provided with 7 ml 0.25% levobupivacaine hourly. The primary outcome measure was the duration of spinal analgesia. Secondary outcome measures include time from spinal analgesia to delivery, total amount of epidurally administered levobupivicaine, adverse effects of neuraxial block and neonatal outcome.
Interventions
DRUGDexamethasone
4mg dexamethasone intrathecally plus levobupivacaine 2.5 mg
DRUGLevobupivacaine
levobupivacaine 2.5 mg
Sponsors
ahmed elsakka
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* ASA physical status I,II patients schedueled for normal vaginal deliveries * age between 18-35 years old
Exclusion criteria
* Patients who refused to participate * complicated pregnancies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| duration of spinal analgesia | 1 day |
Secondary
| Measure | Time frame |
|---|---|
| time from spinal analgesia to delivery | 1 day |
Outcome results
None listed