Age-Related Macular Degeneration
Conditions
Brief summary
This prospective, non-therapeutic study will compare the relative utility of multiple ocular imaging modalities in the detection of the cellular immune response in patients with AMD and related disorders.
Interventions
PROCEDUREmulti-modal cSLO imaging
Sponsors
Unity Health Toronto
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
STUDY EYE Any tentative clinical diagnosis of the following: 1. Early dry AMD (drusen) with clinical suspicion of CNV 2. Late dry AMD (GA) with clinical suspicion of CNV 3. Reticular Pseudodrusen with clinical suspicion of CNV 4. Polypoidal choroidal vasculopathy 5. Retinal Angiomatous Proliferation 6. Central Serous Retinopathy 7. RPE detachment 8. Conversion to wet AMD (CNV) 9. Decade matched controls Inclusion Criteria CONTROL EYE * Subjects \> 18 years of age * Best corrected visual acuity (BCVA) of 20/32 or better
Exclusion criteria
STUDY/CONTROL EYE: * Patients not able to provide consent for the study. * Patients with a poor view of the fundus due to cataract or vitreous hemorrhage. * Patients \< 18 years of age * Patients with known allergy to angiographic dye * Patients with any concurrent unrelated eye diagnosis that would interfere with image acquisition or interpretation (eg advanced diabetic retinopathy, vascular occlusion, uveitis, or others).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visualization of RPE damage and presumptive immune cells | 8 months | Qualitative |
Countries
Canada
Contacts
Primary ContactShelley Boyd, MD
Outcome results
None listed