The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02588196

Enrollment

200

Registered

2015-10-27

Start date

2015-11-30

Completion date

Unknown

Last updated

2015-10-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tuberculous Meningitis

Brief summary

The study aimed to evaluate the relationships between the gene polymorphisms of leukotriene A4 hydrolase(LTA4H) and Dexamethasone treatment for tuberculous meningitis in Chinese patients.

Interventions

DRUGDexamethasone acetate

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

14 Years to No maximum

Inclusion criteria

patients were eligible to enter the study if they met the diagnositic criteria for possible, probable or definite Tuberculosis meningitis(TBM).

Exclusion criteria

Patients were excluded if they were infected with HIV, diagnosed as carcinomatous meningitis, viral meningitis, purulent meningitis, cryptococcus meningitis.

Design outcomes

Primary

Measure	Time frame	Description
MRI	6 month	whether MRI show infarction, hydrocephalus, meningeal enhancement
changes of cerebrospinal fluid	1 year	—
changes of clinical symptoms	1 year	headache duration, duration of fever,presence of cranial nerve damage

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026