The Correlation Between Hair Cortisol Level of Acute Stroke or Its Long Term Disability.

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02587949

Enrollment

Registered

2015-10-27

Start date

2015-11-30

Completion date

2019-11-30

Last updated

2018-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebrovascular Stroke

Keywords

acute cerebrovascular stroke

Brief summary

In patients admitted to hospital with acute cerebrovascular stroke, we want to study the relationship between hair cortisol levels and biomarkers of inflammation and the clinical and radiological severity of the stroke and the degree of neurological disability being tested in three months and one year after.

Detailed description

The study will include patients hospitalized due to an acute cerebrovascular stroke. A number of 30 patients aged 40-70 will be included. Within 48 hours of the event, blood inflammatory biomarkers, and scalp hair sample for cortisol will be taken. All recruited patients will undergo full neurological examination and the severity of the stroke will be rated using NIHSS (National Institutes of Health Stroke Scale). 3 months and one year later neurological examination and rating of neurological disability will be determined using Rankin Scale.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. Patients aged 40-80. 2. Acute cerebrovascular stroke (symptoms that began no more than 72 hours before) 3. Rankin 0-1 before the event

Exclusion criteria

1. Suspicion or known Cushing's syndrome 2. Known adrenal failure 3. Chronic inflammatory disease 4. Active malignancy 5. Acute infectious disease within 4 months before enrollment

Design outcomes

Primary

Measure	Time frame	Description
INL-6	24 months	single blood sample will be drawn to measure INL-6 levels.
Anti Tumor Necrosis Factor alpha	24 months	single blood sample will be drawn to measure Anti Tumor Necrosis Factor alpha levels (pg/ml).
C-reactive protein levels	24 months	single blood sample will be drawn to measure c-reactive protein levels (mcg/dl).
Hair Cortisol level	24 months	single hair sample will be drawn to measure cortisol levels (mcg/dl)

Secondary

Measure	Time frame	Description
TSH	24 months	single blood sample will be drawn to measure Thyroid-Stimulating Hormone (mcIU/ml).
FT4	24 months	single blood sample will be drawn to measure Free Thyroxine (pmol/L) .
FT3	24 months	single blood sample will be drawn to measure Free Triiodothyronine (pmol/L).
Cortisol	24 months	single blood sample will be drawn to measure cortisol levels (mcg/dl).

Countries

Israel

Contacts

Primary ContactMira Koch

mira.koch@b-zion.org.il97248359351

Backup ContactMichal Yeiches

yeiches@gmail.com97248359484

Outcome results