Bilateral Vocal Cord Paresis, Laryngeal Carcinoma, Subglottic Stenosis
Conditions
Keywords
laryngeal carcinoma, bilateral vocal cord paralysis, laryngotracheal stenosis, laser treatment, decannulation, voice, swallowing
Brief summary
The purpose of the study is to compare results of the treatment of tumorous and non-tumorous laryngotracheal stenosis using thulium contact laser versus carbon dioxide laser used in the past.
Detailed description
Laryngotracheal stenosis is a serious disease significantly worsening the quality of life. Impaired breathing often leads to tracheotomy, deterioration of the voice leads to communication problems with others and swallowing problems are often present, as well The main causes of laryngotracheal stenosis are post intubation and post tracheostomy conditions, inflammatory process (often autoimmune), tumors (mainly squamous cell carcinoma and chondroma) and trauma. Within the last years there is substantial shift in the treatment strategy from open surgery to endoscopic techniques. However, surgical treatment is often difficult due to demanding exposure of tumor and problematic margins control. In recent years there has been a development of particular techniques of endoscopic resection of tumors and non-malignant laryngeal glottic and subglottic stenosis using a carbon dioxide (CO2) laser with promising improvement of treatment results. However, CO2 laser has some limitations, particularly in the treatment of tumors spreading into anterior commissure, because CO2 laser beam cannot get around the corner. Moreover, subglottic area is also difficult to be reached by CO2 laser beam. Therefore, contact laser with adjustable manipulators with possibility to bend tip of manipulator according to the actual need seems to be of some advantage.
Interventions
treatment of laryngeal carcinoma using thulium contact laser
treatment of bilateral vocal cord paralysis using thulium contact laser
treatment of subglottic stenosis using thulium contact laser
Sponsors
Study design
Eligibility
Inclusion criteria
1. patients with T1-T2 (some T3) laryngeal carcinoma 2. patients with bilateral vocal cord paralysis treated with partial arytenoidectomy and laterofixation 3. patients with subglottic stenosis treated endoscopically
Exclusion criteria
* non signing of informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of carcinoma recurrence in the patient population | 36 months | The percentage of carcinoma recurrence will be monitored and evaluated within the study subjects. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of decannulation in the patient population | 36 months | The percentage of decannulation will be monitored among the study subjects. |
| Voice quality (Voice Handicap Index) | 36 months | Voice quality will be assessed according to the Voice Handicap Index, which is an acknowledged measurement tool providing precise evaluation of the condition. |
| Swallowing (SWAL-QOL) questionnaire | 36 months | Swallowing will be assessed in the study group using the SWAL-QOL measurement tool (questionnaire) providing precise evaluation of the condition. |
Countries
Czechia