Pneumological Acute Coronary Syndrom (ACS) Phenotyping Aachen

Pneumological Phenotyping of Acute Coronary Syndrom (ACS) Patients Concerning Concomitant Chronic Obstructive Pulmonary Disease (COPD)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02587481

Acronym

PAPA

Enrollment

100

Registered

2015-10-27

Start date

2015-11-30

Completion date

2017-05-31

Last updated

2017-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Coronary Syndrom, Chronic Obstructive Pulmonary Syndrom

Keywords

Acute coronary syndrom, Chronic obstructive pulmonary disease, Myocardial infarction, Blood based biomarkers

Brief summary

In this open, monocentric, observational study acute coronary syndrom (ACS) patients will be characterized by pneumological examination concerning a concomitant chronic obstructive pulmonary disease (COPD). Often COPD coexists with ACS; therefore ACS patients benefit either from prevention or potential therapy of chronic hypoxia.

Detailed description

In this study patients with either non ST-segment-elevation myocardial infarction (NSTEMI) or ST-segment-elevation myocardial infarction (STEMI) will be included. After amnesis patients will undergo blood withdrawal, blood-gas analysis and examinations concerning pulmonary function (Bodyplethysmography). In addition to routine blood withdrawal for differential blood count, 9 ml blood sample is takenfor molecular analysis of relevant prognostic chronic obstructive pulmonary disease (COPD)-blood based biomarkers, an for establishing a library of biomaterial in form of a biobank.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Written declaration of consent * Patients with acute myocardial infarct which can be either non ST-segment-elevation myocardial infarct (NSTEMI) or ST-segment-elevation myocardial infarct (STEMI), in both cases exaggeration of cardiac ischaemic markers

Exclusion criteria

* Patients not fulfilling the incluson criterias or: * Pregnant or breastfeeding women * Participation in other studies * Persons in depency from the sponsor or working with the sponsor * Persons without mental ability or capacity to understand and follow the instructions of the investigator

Design outcomes

Primary

Measure	Time frame
Number of patients with Acute Coronary Syndrom (ACS) and concomitant Chronic Obstructive Pulmonary Disease (COPD)	During 1-2 hours (at time of examination)

Secondary

Measure	Time frame
Molecular analysis of relevant blood based chronic obstructive pulmonary disease (COPD) biomarkers	An average of 1 day

Countries

Germany

Outcome results