Cluster Headache and SPINK-1 Gene

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02585739

Enrollment

Registered

2015-10-23

Start date

2011-10-31

Completion date

2015-07-31

Last updated

2015-10-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Episodic or Chronic Cluster Headache

Brief summary

Cluster headache (CH) is a rare, excruciating primary headache disorder. A genetic basis has been suggested by family and twin studies, but the mode of transmission seems to vary and the amount of heritability is unclear. The number of genetic association studies investigating variants implicated in the pathophysiology of CH is limited. The HCRTR2 1246G \> A and the ADH4 925A \> G polymorphisms have been associated with CH. The former has been confirmed and may affect the hypothalamic hypocretin system. The aim of the present study was to investigate the possible link between SPINK 1 gene and cluster headache.

Interventions

GENETICblood sample

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SCREENING

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* People aged 18 or over * Patient consulting in Marseille's or Nice's Pain departments * Patient agreeing to participate to the research study * Patient with health insurance

Exclusion criteria

* People aged under 18 * Patient refusing to participate to the research study * Patient with deprivation of liberty

Design outcomes

Primary

Measure	Time frame
SPINK1 genotyping	2 months

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026