Hyperglycemia
Conditions
Keywords
Critically ill, Diet, Blood glucose
Brief summary
In this randomized, double-blind clinical trial, eligible hospitalized ICU patients with EN will be included. Patients will be divided into two groups. The control group with the standard EN and intervention group with high fat EN. 50% of the total fat will be provided by olive oil. Nutritional intake record form will be completed and daily calorie intake will be calculated. High fat EN feeding will be offered for 15 consecutive days maximally. At the end of the study mean blood glucose, duration of hospitalization and rate of infection will be compared in two groups.
Detailed description
In this randomized, double-blind clinical trial, 88 eligible hospitalized ICU patients with EN will be included. Written consent form will be completed. Physical examination will be done by specialist and nutritional care process will be offered by an RD. Demographic, laboratory and nutritional data will be extracted and entered in prepared form. Venous blood samples will be taken and laboratory values will be measured and recorded at specified times. Patients will be divided into two groups. The control group with the standard EN (Protein; 20% carbohydrate; 50% and fat; 30% from total calories) and intervention group with high fat EN (Protein; 20% carbohydrate; 35% and fat; 45% from total calories). 50% of the total fat will be provided by olive oil. Any feeding rout such as naso - gastric , Percutaneous endoscopic gastrostomy (PEG ) or Percutaneous endoscopic jejunostomy (PEJ) with Intermittent feeding protocol will be accepted feeding method . Nutritional intake record form will be completed and daily calorie intake will be calculated. High fat EN feeding will be offered for 15 consecutive days maximally
Interventions
OTHERHigh Fat Enteral Nutrition
Diet in high fat group will be 20% from protein, 45% from fat and 35% from carbohydrate
Sponsors
Shahid Beheshti University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Being on Enteral Nutrition * BS≥ 200mg/dl * Without Renal and Liver Failure * Without Hyperlipidemia and Nephrotic Syndrome * Without Infection * Without Obesity
Exclusion criteria
* Death or Discharge before Day 7
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood Glucose | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Length of Stay in ICU | 1 year |
| Occurrence of Infection | 1 year |
Countries
Iran
Outcome results
None listed