Project BEST: Buprenorphine Entry Into Substance Abuse Treatment

Depression, Hepatitis C, Chronic, HIV Infections, Opioid-related Disorders

Opioid dependence, HIV/AIDS, Hepatitis C, Severe mental illness, Injection Drug Use

Project BEST is a clinical project funded by the Substance Abuse and Mental Health Services Administration (SAMHSA) to increase treatment to opiate dependent patients with mental illness in New Haven, CT and to prospectively follow everyone enrolled in buprenorphine care for as long as the individual takes buprenorphine to track the success of buprenorphine for the maintenance of opiate dependence.

The investigators propose to create a prospective cohort that will track outcomes for an opiate dependent population on buprenorphine maintenance. Individuals who have already decided to undergo buprenorphine treatment in Project BEST will be invited to participate in the following data collection process. The investigators propose the following series of data collection to assess clients during their time in the cohort: GPRA, supplemental instrument, ASI, SCID, COWS, Urine toxicology. Patients who are enrolled will enter a standardized, manual based weekly counseling regimen. Urine toxicology will be performed a minimum of twice monthly, but will not occur at the same times monthly to decrease the probability of sampling error. This is a prospective cohort to follow a group of individuals on buprenorphine treatment. The goal of this prospective cohort is to generate thoughtful observations. Specific items of interest which will be compared with age, race matched historical controls on methadone will be: 1. Changes in addiction severity over treatment time 2. Changes in sexual risk behaviors and injection practices 3. Improvements in urine toxicology 4. Co-occurring mental illness

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