Type 2 Diabetes, Gestational Diabetes, Pre-diabetes
Conditions
Brief summary
In this prospective observational cohort study, women representing the full spectrum of gestational glucose tolerance status are undergoing longitudinal cardiometabolic characterization at regular intervals in the years after the index pregnancy.
Detailed description
In this prospective observational cohort study, women reflecting the full spectrum of glucose tolerance in pregnancy (from gestational diabetes mellitus (GDM) to lesser degrees of gestational glucose intolerance to those with completely normal glucose tolerance) are being recruited in late 2nd trimester. This cohort of women thus carries a broad range of risk for the future development of type 2 diabetes (T2DM) and cardiovascular disease. At regular intervals in the years after the index pregnancy, this cohort of women is undergoing serial cardiometabolic characterization, including assessment of glucose tolerance, beta-cell function and insulin sensitivity. The longitudinal changes over time in this cohort should provide insight into the early pathophysiology and natural history of T2DM and cardiovascular disease.
Interventions
OTHERThere is no intervention. An exposure of interest is glucose tolerance status in pregnancy
Sponsors
Canadian Institutes of Health Research (CIHR)
Mount Sinai Hospital, Canada
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Pregnant women
Exclusion criteria
* Pre-existing diabetes before the index pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose tolerance status | 10 years after pregnancy | Glucose tolerance is assessed on oral glucose tolerance test |
Countries
Canada
Contacts
Primary ContactRavi Retnakaran, MD
Outcome results
None listed