Nail Abnormalities
Conditions
Keywords
Nail gel, Nail surface abnormality, Efficacy
Brief summary
Nail surface abnormalities is any conditions that affect the nail matrix or nail bed which cause nail plates grow defectively. Common nail surface abnormalities are pitting nails, longitudinal ridging, and transverse ridging/Beau's line. Aging nails usually have nail surface abnormalities as well. Nail gels are artificial nails used widely for aesthetic purposes. Although, their cosmetic use is increasing with day by day, their usefulness in conditions such as nail biting, brittle nails, and ingrown toe nails has been reported. Moreover, a previous study reported the benefits of nail gels in terms of improving nail surface abnormalities like pitting nails, trachyonychia, and onychoschizia. This study was conducted to evaluate the efficacy of nail gel containing Glycerin which has humectant effect and Artemisia Abrotanum extract which has anti-fungal/bacterial activities in finger nail surface abnormalities.
Detailed description
Evaluation of nail surface abnormality can be done by using Visiometer® (bioengineering measurement) and dermoscope. Both techniques are non-invasive. Artemisia Abrotanum extract has been used as ingredient in cosmetic products and its safety has been declared. Undesirable events from external using products containing this substance have never been reported yet. Nail gel product in this study has been approved as a cosmetic product by Food and Drug Administration of Thailand (Thai FDA).
Interventions
DRUGNail gel
apply nail gel on affected nails twice daily for 2 months
Sponsors
Mahidol University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age 18 years old or above 2. Being diagnosed nail surface abnormalities stably more than 3 months
Exclusion criteria
1. Having severe or uncontrolled concomitant diseases 2. Having nail infection 3. History of manicure within the last 1 month 4. Use of Biotin or other nail modifying drugs within the previous 3 months 5. Pregnancy or lactation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement overall nail surface abnormalities | 2 weeks and 8 weeks | Number of nails of each participant with change/improvement nail surface using clinical assessment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Improvement roughness of nail surface abnormalities | 2 weeks, and 8 weeks | Number of nails of each participant with change/improvement nail surface using bioengineering measurement |
| Increase nail hydration | 2 weeks, and 8 weeks | Number of nails of each participant with the increase of nail hydration using bioengineering measurement |
| Patients's satisfaction | 2 weeks and 8 weeks | good patients's satisfaction outcome by self-questionnaire |
Countries
Thailand
Contacts
Primary ContactSumanas Bunyaratavej, MD
Outcome results
None listed