Anesthesia
Conditions
Keywords
Minimum Alveolar Concentration
Brief summary
The purpose of this study is to find difference in Minimum Alveolar Concentration(MAC) for maintaining Bispectral Index (BIS) below 50 between chronic opioid users and opioid naive patients.
Detailed description
1. Patients selection in elective surgery which need general anesthesia. 2. MAC BIS50 data was collected in each patients (by blinded investigator) 3. The data collection will be continued for enough sample size for using Dixon Up Down Method Analysis 4. After Data collection, MAC BIS below 50 will be analyzed in both groups ( Chronic opioid users versus opioid naive patients)
Interventions
OTHERHistory for opioid use
Sponsors
National Cancer Center, Korea
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
41 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
* The patients(ASA class I-III) who receive elective surgery * signed in informed consent to participate in this trial voluntarily.
Exclusion criteria
* History of Monoamine Oxidase (MAO) inhibitor use * Chronic alcoholics * Acute alcohol abuser * Contraindication for inhalation agent use (Sevoflurane) * BMI \>30 * History of medication use, which affect in the minimum concentration of sevoflurane;(barbiturates, chlorpromazine, diazepam, hydroxyzine, verapamil, marijuana) * Craniotomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Minimum Alveolar Concentration below BIS 50 in Sevoflurane; percentage (eg: 1.2%) | 15 minutes after pre-set of the concentration of sevoflurane | Dixon's up down method is applied in this study. So pre-set concentration of sevoflurane will be used in each group. |
Countries
South Korea
Outcome results
None listed