In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis (ALS)

In-situ Cytokines Expression in the CNS in Amyotrophic Lateral Sclerosis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02582385

Enrollment

Registered

2015-10-21

Start date

2012-10-31

Completion date

2015-02-28

Last updated

2015-10-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amyotrophic Lateral Sclerosis

Keywords

Amyotrophic lateral sclerosis (ALS), Cytokines, Neuropathology

Brief summary

The investigators aim at exploring the differential/topographical in-situ expression of cytokines in the central nervous system (CNS) of patients who died with amyotrophic lateral sclerosis (ALS), using archived histopathology slides and residual paraffin blocks from autopsied cases. Previous studies from the investigators and other groups showed that inflammatory cytokines are implicated in several neurological affections, particularly neurodegenerative conditions. However, in-situ cytokine expression has never been studied so far in ALS. The investigators wanted to see if these neuro-mediators are involved in the neuromolecular chain/cascade underlying ALS.

Interventions

OTHERin-situ cytokine expression

Study design

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* patients who died with amyotrophic lateral sclerosis, having been autopsied.

Exclusion criteria

* N/A

Design outcomes

Primary

Measure	Time frame	Description
in situ cytokine detection: interleukin 18	retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005	IHC detection on histopathology sections of paraffin embedded brain tissue.
in situ cytokine detection: interleukin 1	retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005	IHC detection on histopathology sections of paraffin embedded brain tissue.
in situ cytokine detection: interleukin 6	retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005	IHC detection on histopathology sections of paraffin embedded brain tissue.
in situ cytokine detection:TNF-a	retrospective study performed on archived paraffin blocks, autopsies performed between 2000 and 2005	IHC detection on histopathology sections of paraffin embedded brain tissue.

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026