Remote Ischemic Preconditioning in Elective Percutaneous Interventions

Effect of One Cycle Remote Ischemic Preconditioning on Myocardial Injury After Percutaneous Coronary Interventions in Patients With Stable Coronary Artery Disease

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02581618

Enrollment

102

Registered

2015-10-21

Start date

2015-05-31

Completion date

2016-02-29

Last updated

2016-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic Reperfusion Injury, Myocardial Ischemia

Keywords

ischemic preconditioning, myocardial injury, percutaneous coronary intervention

Brief summary

Myocardial injury occurs after percutaneous coronary intervention due to micro emboli, ischemia-reperfusion injury or side branch occlusion. 3 cycles of ischemic preconditioning has been shown to be useful in preventing myocardial injury but it is not suitable to perform it especially in ad hoc interventions. In this study the investigators aim is to show whether one cycle remote ischemic preconditioning will be enough to prevent myocardial injury during percutaneous coronary intervention.

Detailed description

About in one third of elective percutaneous coronary interventions (PCI) troponin release occurs showing myocardial necrosis. And it has been shown that myocardial necrosis due to coronary interventions has also adverse effects on long term prognosis. Beneficial effects of of ischemic preconditioning in elective PCI and in coronary artery bypass surgery has been shown in several studies. In most of the trials 3 cycles of ischemia was performed, but this is time consuming and it's not suitable to apply it, in ad-hoc interventions. The investigators found one study showing that one cycle will also be enough to prevent troponin elevation after elective PCI. The investigators aim was also to show that one cycle preconditioning performed just before coronary intervention will also be useful in preventing myocardial necrosis due to elective PCI.

Interventions

OTHERremote ischemic preconditioning

Blood pressure cuff inflation up to 200mmHg in the non-dominant arm before guiding catheter engagement

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients with stable coronary artery disease, in whom percutaneous coronary intervention is planned after coronary angiography * Patients with informed consent

Exclusion criteria

* Acute or chronic renal failure (Creatinin clearance \<60ml/dk) * Acute heart failure * Presence of hemodynamic instability * Left main interventions * Acute Coronary Syndrome * Patients in whom cuff inflation is contraindicated in upper extremities (fistula, lymphoedema etc) * Patients using nicorandil, glibenclamide or trimetazidine * Patients not accepting the study * Presence of troponin elevation before intervention * Presence or suspicion of pregnancy

Design outcomes

Primary

Measure	Time frame
hs-Troponin elevation	after 16 hours

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026