Carcinoma, Hepatocellular
Conditions
Keywords
Radiotherapy, General Surgery
Brief summary
This study aims to evaluate the effectiveness of radiotherapy before surgery in high-risk relapse hepatocellular cancer patients.
Interventions
RADIATIONradiotherapy
radiotherapy before surgery
Sponsors
Beijing Hope Run
Peking Union Medical College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1. Clinical diagnosis of HCC 2. In high risk of recurrence of HCC but still can endure palliative resection 3. KPS scores are \>90 4. With Child-Pugh Class A liver funcion, serum bilirubin\< 1.5\*normal maxism; ALT and AST\< 1.5\*normal maxism; normal creatinine and urea nitrogen; WBC\>4×109/L, Hb\>110g/L, PLT\>90X109/L. 5. Have signed informed consent
Exclusion criteria
1. HCC cannot be operated 2. With Child-Pugh Class B/C 3. Have other organ cancer, excluding curative non-melanotic skin cancer and carcinoma in situ of cervix 4. Have other severe disease 5. With active hepatitis 6. Have accepted local radiation therapy in other hospitals 7. KPS scores≤70 8. Tumor edges cannot be defined 9. Have severe cirrhosis complication 10. Intensity modulated radiation therapy cannot reach required dose 11. Cannot cooperate 12. Lactant or pregnant 13. Cannnot be informed
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mortality | 5 years |
Countries
China
Contacts
Primary ContactFAN WU
Outcome results
None listed