Brain Activity in Adults With ADHD During Neuropsychological Tasks

Brain Activity and Functional Connectivity in Adults With Attention-Deficit Hyperactivity Disorder (ADHD) During Tasks of Motor Inhibition and Cognitive Switching

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02578342

Enrollment

Registered

2015-10-16

Start date

2015-08-31

Completion date

2020-11-30

Last updated

2022-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Attention Deficit Hyperactivity Disorder (ADHD)

Brief summary

The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD.

Detailed description

Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adolescents. It is characterized by inattentive, hyperactive, impulsive behaviour and neuropsychological deficits. In 40-60% of cases emerge in childhood and persists into adulthood. The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested. Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.

Interventions

DEVICEMRI

Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Participant is between 20-55 years old * Participant is not pregnant

Exclusion criteria

* Participant is not able to consent him/herself * Suspected or proven pregnancy * Nursing * Neurological diseases that could interfere with a diagnosis of ADHD * Psychiatric comorbidity under treatment * Previous history of psychiatric medication * Substance abuse * Intelligence quotient\<75 * Claustrophobia * Electrical simulator nerve or bone * Implanted medication infusion pump * Cerebral aneurysm clips * Unstable medical condition

Design outcomes

Primary

Measure	Time frame	Description
Changes in blood oxygenation level dependency (BOLD)	2 hours	The study consist solely of one MRI examination performed within 2 hours.

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 15, 2026