Associations Between Periodontitis and Autoimmune Antibodies in Rheumatoid Arthritis Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02577679

Enrollment

Registered

2015-10-16

Start date

2015-06-30

Completion date

2015-11-30

Last updated

2015-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis, Rheumatoid Arthritis, Autoimmunity,

Keywords

Dentistry

Brief summary

The aim of this case control study is to explore the possible association between periodontal destruction and serum anti-CCP antibodies in RA patients and healthy subjects.

Detailed description

In patients with RA, the anti-CCP antibody titer seems positively correlated to their periodontal destruction and disease activity in comparison with healthy subjects.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

60 Years to 80 Years

Healthy volunteers

Yes

Design outcomes

Primary

Measure	Time frame	Description
Serum level of anti-cyclic citrullinated peptide/protein antibody	Base line	Lower then 7 Unit/milliliter: negative 7-10 Unit/milliliter: weak positive Higher then 10 Unit/milliliter: positive
Periodontal pocket depth and clinical attachment level	Baseline	Lower then 4 millimeter: normal Higher then 4 millimeter: diseased/previously diseased

Secondary

Measure	Time frame	Description
Serum level of anti-mutated citrullinated vimentin	Baseline	Recorded in Unit per milliliter
Serum level of interleukin 6	Baseline	Recorded in picogram per milliliter
Serum level of interleukin 17	Baseline	Recorded in picogram per milliliter
Serum level of tumor necrotic factor alpha	Baseline	Recorded in picogram per milliliter

Countries

Taiwan

Outcome results