End-stage Renal Disease
Conditions
Keywords
Survival, Hemodiafiltration, End-stage renal disease, Hemodialysis
Brief summary
A retrospective cohort study was conducted in 66 end-stage renal disease patients who underwent high-efficiency hemodiafiltration technique in King Chulalongkorn Memorial Hospital between 2001-2013 to determine the survival rate as well as other long-term outcome.
Detailed description
Growing evidences suggested the superiority of high-efficiency hemodiafiltration (HDF) which could provide both diffusion and convection in a single therapy compared with the conventional hemodialysis. However, the long-term, upto 10 years, outcome still limited. This retrospective cohort study was conducted in 66 end-stage renal disease patients who underwent high-efficiency hemodiafiltration technique in a single-center, King Chulalongkorn Memorial Hospital, between 2001-2013 to determine the survival rate as well as other long-term outcome
Interventions
OTHERHemodiafiltration
Hemodiafiltration treatments were prescribed to the patients as their long-term renal replacement therapies
Sponsors
Chulalongkorn University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Aged 18 years or more * Be diagnosed end-stage renal disease for more than one year * Have been regularly received long-term hemodiafiltration for more than 6 months.
Exclusion criteria
* Patients who received hemodiafiltration less than 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival rate | 10 years | The Kaplan-Meier survival curve and mean survival time will be demonstrated for primary outcome. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of survival differences between patients who start renal replacement therapy with HDF and who switched from hemodialysis as well as between diabetic and non-diabetic patient. | 10 years | Survival differences between groups will be evaluated with the Kaplan-Meier method and compared using the log-rank test. The comparative groups include: * Patient who start renal replacement therapy with HDF (incident cases) vs. who switched from hemodialysis (prevalence cases) * Diabetic vs. Non-diabetic patients |
| Factors that associated with all-cause mortality | 10 years | univariate and multivariate analysis the factors that might affected the long-term outcomes. The factors include dialytic parameters (spKt/Vurea, TAC urea), nutritional parameters (nPNA, albumin), inflammatory parameter (hsCRP), and biochemical parameters (BUN, Cr, Ca, Phosphate, iPTH, beta2-microglobulin, Hb, Ferritin, Transferrin saturation, Cholesterol, Triglyceride, HDL, and LDL) |
Countries
Thailand
Outcome results
None listed