Pain
Conditions
Brief summary
The aim of this prospective randomized study was to evaluate the impact of peroperative pupillometry monitoring on per and post-operative opioid consumption in major gynecological surgery. All patients were anesthetized with TCI of propofol and remifentanil. In the intervention group, peroperative remifentanil target was guided by pupillometry. In the other group, remifentanil was administered according to standard practice.
Interventions
DRUGPropofol
TCI
DRUGRemifentanil
TCI
DEVICEVideopupillometer Algiscan
pupillary diameter measurement every five minutes per-operatively
OTHERStandard practice
remifentanil administration left to the discretion of the anesthesiologist in charge according to standard practice
Sponsors
Pr Isabelle CONSTANT
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-II * Elective gynecological surgery * No ophtalmologic or neurologic disease * No chronic analgesic medication * Expected length of surgery 60 minutes minimum
Exclusion criteria
* ophtalmologic or neurologic disease * chronic analgesic medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| peroperative remifentanil consumption in µg/kg/min | duration of surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| post-operative morphine requirements in mg/kg | 24 hours | includes initial morphine titration and subsequent PCA use |
| peroperative propofol consumption in mg/kg/h | duration of surgery | — |
Countries
France
Outcome results
None listed