Pituitary Adenoma
Conditions
Keywords
Glucose Fluctuation, GH-Secreting Adenoma, Cushing Syndrome
Brief summary
Glucose fluctuations present not only in patients with diabetes mellitus but also in subjects with normal glucose tolerance or impaired glucose regulation. People with Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome are at risk of impaired glucose metabolism. Glycemic variability is poorly studied in the nondiabetic individuals. The aim of the study is to investigate the characteristics of glucose fluctuations in the newly diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome individuals.
Detailed description
Glucose fluctuations present not only in patients with diabetes mellitus but also in subjects with normal glucose tolerance or impaired glucose regulation. Compared with traditional monitoring methods, continuous glucose monitoring system(CGMS) techniques provides a much more detailed understanding of shifting blood glucose levels throughout the day.It is considered reliable to evaluate glucose variability not only in patients with diabetes but also in nondiabetic individuals. People with Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome are at risk of impaired glucose metabolism and developing diabetes mellitus.Some researchers have shown that 15-30% Growth Hormone-Secreting Pituitary Adenoma are suffering from diabetes, 15-36% impaired glucose regulation. The rate of Cushing Syndrome individuals is 10-30% and 40-45% separately. Glycemic variability is poorly studied in the nondiabetic individuals and has not been studied in the newly diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome individuals. In this study CGM was used to dynamically monitor patients being newly diagnosed with Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome.
Interventions
DEVICEcontinuous glucose monitoring
Patients newly diagnosed GH-releasing pituitary adenoma or Cushing Syndrome in our department will be monitored blood glucose by CGMS Gold.
Sponsors
Huashan Hospital
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* •newly diagnosed GH-releasing pituitary adenoma * •newly diagnosed Cushing Syndrome
Exclusion criteria
* •history of diabetes mellitus and being treated with drugs * •being treated with drugs which affect glucose metabolism in the lately 3 months * •with other hormones affecting glucose metabolism secreted abnormally by pituitary * •serious comorbidity like malignant tumour, severe hepatosis or nephropathy, serious hypertension(blood pressure\> 180/110mmhg) * •pregnant or breastfeeding women * •patients allergic to patches or metal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Continuous glucose profiles of mean data of 24-hour continuous glucose monitoring by the CGMS Gold | 3 days | The monitoring results consisted of one curve and 5 parameters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The mean amplitude of glycemic excursion of newly diagnosed GH adenoma patients | 3 days | The mean amplitude of glycemic excursion of newly diagnosed GH adenoma patients during the 3 days monitored by CGMS Gold |
| The mean amplitude of glycemic excursion of newly diagnosed Cushing Syndrome patients during the 3 days monitored by CGMS Gold | 3 days | The mean amplitude of glycemic excursion of newly diagnosed Cushing Syndrome patients during the 3 days monitored by CGMS Gold |
| The correlation of MAGE and IGF-1 in newly diagnosed GH adenoma patients | 6 months | By compared with the outcomes after treated by SSAs or surgery we want to get weather there is a correlation between MAGE and IGF-1 in GH adenoma patients |
| The correlation of MAGE and cortison in newly diagnosed Cushing Syndrome patients | 6 months | By compared with the outcomes after treated by surgery we want to get weather there is a correlation between MAGE and cortison in Cushing Syndrome patients |
Countries
China
Outcome results
None listed