Language Impairment, Hearing Loss
Conditions
Keywords
dyslexia, training, auditory rehabilitation, hearing loss, evoked potentials, dichotic, plasticity, noise
Brief summary
The ability to encode the speech signal is determined by ascending and descending auditory processing. Difficulties in processing these speech signals are well described at the behavioral level in a specific language disorder. However, little is known about the underlying pathophysiological mechanisms. The assumption is that we should observe a degradation of the signal provided by the ear in the deaf subject while in case of specific language impairment it would be a phonemic disorder (possibly linked to a processing disorder auditory). The two population groups should therefore have different abnormalities of their central auditory process - which could be modified by the target remediation for each group.
Interventions
OTHERE-learning
Management of auditory processing disorders with serious game (E-learning)
DEVICEHearing aids fitting
Symmetrical hearing loss which are fitted with binaural hearing aids for the first time
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
For all subjects: * native French speaker * no medical treatment for behavior or neurological disorders * normal or corrected vision * right-handed * normal otorhinolaryngology examination * valid affiliation to social security * no participation to another research study For the normal-hearing subjects * normal tonal hearing thresholds * normal tympanometry For the subjects without specific language impairment * aged from 6 ro 40 * normal school attendance without scholastic retardation * normal intellectual level * normal for age reading skills * no delayed speech (expression & production) For the children with specific language impairment * aged fom 8 to 18 * persistent specific literacy difficulties with reading levels at least 18 months behind that of their peers * normal intellectual level For the hearing impaired subjects * age from 18 to 70 * first auditory rehabilitation * bilateral and symmetric hearing loss (±10 dB) with hearing thresholds between 0 and 25 dB at 0.25 kilohertz, 0 and 35 dB at 0.5 kilohertz, 0 and 50 dB at 1 kilohertz, 25 and 70 dB at 2 kilohertz, 25 and 80 dB at 3 kilohertz, 30 and 80 dB at 4 kilohertz
Exclusion criteria
* non signed assent * treatment for depression, epilepsy, Parkinson's or alzheimer's disease during more than 6 months * physical health deficiency * mental retardation * neurological or psychiatric disease incompatible with testing procedure For children * known problem of hearing loss or chronic middle ear disease whic compromized the hearing status * schooling in a foreign language * foreign language spoken at home with both parents
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline speech auditory brainstem and late responses (composite and objective measure) in response to syllables (behavioral measure) | Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline | Spectro-temporal analysis of speech auditory brainstem and late responses : The speech brainstem and cortical responses are simultaneously obtained in response of different selected syllables from a continuum (selected by using a phonemic identification test) which is presented throughout a behavioral categorical procedure |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline medial olivocochlear system (MOCS) functioning measured using the contralateral suppressive effect of transient evoked otoacoustic emissions (composite measure) | Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline | Measurement of the contralateral suppressive effect of transient evoked otoacoustic emissions (expressed as Equivalent Attenuation) |
| Change from Baseline dichotic skills measured using central auditory processing tests (composite measure) | Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline | Presentation of different speech material to both ears simultaneously |
| Change from Baseline speech-noise listening skills measured using logatomes tests (composite measure) | Arms 2 and 3: Baseline and 5 weeks / Arms 5 and 6: Baseline and 6 months / Arms 1 and 4: Baseline | Presentation of disyllabic words in presence of increasing noise levels |
Countries
France
Outcome results
None listed