Mild Cognitive Impairment
Conditions
Keywords
Mild Cognitive Impairment, Magnetic Resonance Imaging
Brief summary
Walking, Brain and Functional Magnetic Resonance Imaging Study of motor representations in healthy subjects and amnesic MCI.
Detailed description
Review and compare mapping brain activation in Magnetic Resonance Imaging about healthy subjects according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination of the walk.
Interventions
RADIATIONBrain MRI
Brain MRI (Magnetic Resonance Imaging) brain is a painless test that allows to visualize the different brain structures. Korvit, device made up of 2 shoes which reproduces the feeling to go. The Korvit® system appears possible to analyze the activated cerebral zones and to thus try to better understand the operation of the brain during walk. The GAITRite is a carpet for recording the walking operating parameters
Sponsors
University Hospital, Angers
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Obtaining the signature of consent to participation in the study * Age above 18 years * Lack dementia as NICDS-ADRDA criteria * Lack of pre-existing musculoskeletal disorders, regardless of the cause (except MCI). * Absence of a history of stroke or other cerebrovascular disease with spinal sensorimotor sequelae. * No cons-indication for performing a brain MRI. * Witennses, population of young (\<40 years) * Witnesses ,population of older subjects (\> 60 years) * Witnesses Lack of MCI * MCI patients, criteria MCI criteria according to Dubois
Exclusion criteria
: * Refusal of MRI. * Contraindications to brain MRI.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Review and compare mapping cerebral activation in brain MRI | One day | Review and compare mapping brain activation in healthy about MRI according to age (\<40 years and\> 60 years) and MCI through the combination of two paradigms: on mechanically simulated by Korvit® boots and imagination the walk. The primary endpoint is the analysis of fMRI brain mapping in accordance with the different paradigms of acquisition. The MRI data will be the subject of a specific statistical treatment, via dedicated software, which will be implemented under the control of the investigators who have conducted such an fMRI analysis in previous studies. Various brain mapping can be established from the data collected. It may include statistical comparisons between different preselected regions, and different experimental conditions, or correlation studies between brain activation and clinical parameters. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking. | One day | Review and compare mapping brain activation in healthy subjects and MCI MRI in imagination alone walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters |
| Study of differences in terms of activation of brain mapping | One day | Study of differences in terms of activation of brain mapping between mechanical stimulation task arch simulating the place of the step (pace to 120 steps per minute) and a random mechanical stimulation (not reproducing the place of the pitch) . the secondary endpoint will be the analysis of spatiotemporal gait parameters |
| study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI. | One day | study of functional connectivity of sensorimotor cortex obtained by fMRI resting in the subject MCI. the secondary endpoint will be the analysis of spatiotemporal gait parameters |
| study of the potential effects on muscle activation, and autonomic nervous system | One day | study of the potential effects on muscle activation, and autonomic nervous system of plantar mechanical stimulation reproducing walking. the secondary endpoint will be the analysis of spatiotemporal gait parameters |
Countries
France
Outcome results
None listed