Healthy
Conditions
Keywords
volunteers, oat, phenolic acid, bioavailability
Brief summary
A diet rich in whole grain is inversely associated with cardiovascular disease risk and this benefit could be partly attributed to the phenolic acid content of whole grains. The exact absorption, metabolism and excretion of whole grain phenolic acids, however, is not fully understood. In a small human intervention trial, the investigators will investigate to what extent phenolic acids from whole grain oats are absorbed, excreted in urine and how they are metabolised.
Interventions
DIETARY_SUPPLEMENTOat bran
66g oat bran made up in 350ml skimmed milk
DIETARY_SUPPLEMENTrefined grain
refined grain product and 350ml skimmed milk
Sponsors
PepsiCo Global R&D
University of Reading
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
25 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Males * 25 to 65 years old
Exclusion criteria
* Allergies to oats * Parallel participation in another research project * Having flu vaccination or antibiotics within 3 months of trial start * Taking food supplements within 3 months of trial start * Past or existing medical history of vascular disease, diabetes, hepatic, renal, gastrointestinal, haematological, neurological, thyroidal disease or cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in phenolic acid metabolite excretion | Baseline and 48 hours |
Countries
United Kingdom
Outcome results
None listed