Functional Brain Mapping
Conditions
Keywords
MEG, EEG, MRI, Brain mapping, functional imaging, brain computer interface
Brief summary
The study aims at mapping the magnetoencephalographic (MEG) activities induced in normal volunteers by tapping the finger .
Detailed description
Normal healthy (20) volunteers and tetraplegic patients(10) will be submitted to the temporo-spatial mapping of their brain activity, both sensory and motor, induced by a simple behavioral task, consisting on tapping with the finger on a detection pad. This will be done in a light and then dark environment, on a rythm spontaneous and then paced by sound bips. Accelerometric recording will provide the three dimensionnal displacements of the finger as well as the time code. Brain activity is simultaneously recorded using MEG (306 channels) and EEG (64 channels. Data will be processed by an INPLS algorithm to detect the predictors of activity, their location and time-course. 3D mapping data will be matched with the patient's anatomy provided by 1.5T MRI previously performed. The aim of the study is to prepare the strategy of implantation of multielectrodes ECoG implants to restore motility in tetraplegic patients in a human BCI protocol currently under development.
Interventions
BEHAVIORALPsychomotor tasks
the acquisition of data will be performed in one unique session no drug administration no surgery
Sponsors
Commissariat A L'energie Atomique
University Hospital, Grenoble
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or Female between 18 and 70 years * Informed consent * Benefiting from Social Security * French or english speaking, to understand study procedure * Tetraplegic patients : traumatic injury of the cervical spine with retained respiratory autonomy and without associated head injury
Exclusion criteria
* Contra-indication to MRI * Claustrophobia * Mental disorders * Pregancy * All categories of protected persons
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MEG records for functional brain mapping | one hour study | This study is not a therapeutic clinical study. No treatment is being delivered. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MEG measurements during psychomotor tasks | one hour study | MEG records induced by finger tapping will be performed either randomly or following sound bips pacing. |
| EEG measurements during psychomotor tasks | one hour study | EEG records induced by finger tapping will be performed either randomly or following sound bips pacing. |
Countries
France
Outcome results
None listed