MEOPA Versus Local Anesthesia for Analgesia During Chorionic Villus Sampling.

MEOPA (Equimolar Mix of Oxygen and Nitrogen Monoxide) Versus Local Anesthesia for Analgesia During Chorionic Villus Sampling.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02573987

Acronym

MELIBIO

Enrollment

192

Registered

2015-10-12

Start date

2013-03-13

Completion date

2016-12-27

Last updated

2018-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Brief summary

determine if efficiency of MEOPA anesthesia is at least equivalent to local anesthetics into the chorionic villus sampling in the first trimester of pregnancy

Detailed description

Compare anxiety discomfort and side effects

Interventions

DRUGOxygen/nitrous oxide equimolar mix

an experimental strategy inhalation by means of a breathing mask diffusing MEOPA

DRUGLidocaine

standard strategy by local injection anesthesia of lidocaine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* pregnant * 18 and over * monofetal pregnancy * chorionic villus sampling medical indication without contra indication * informed consent signature

Exclusion criteria

* pregnant under 18 * multiple pregnancies * pregnancy inferior 11 aw * no informed consent signature

Design outcomes

Primary

Measure	Time frame	Description
Analgesia efficiency	5 min after procedure	assessment of pain with visual analog scale

Secondary

Measure	Time frame	Description
assessment of anxiety	5 min after biopsy	assessment of anxiety with visual analog scale

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026